The unexpected dangers of gum disease

decembrie 18, 2019by Everest Whiting0

Gum disease is common and unpleasant, but, according to a growing body of evidence, it could also play a role in a surprising range of seemingly unrelated health problems. Cleaning your teeth may be even more important than you thought. Plaque — a sticky substance that contains bacteria — builds up on teeth. If it is not brushed away, the bacteria can irritate the gums.

The gums may then become swollen, sore, or infected; this is referred to as gingivitis. In general, gum disease can be treated or prevented by maintaining a good oral health regime. However, if it is left to develop, it can result in periodontitis, which weakens the supporting structures of the teeth.

Gum disease, which is also called periodontal disease, is widespread. According to the Centers for Disease Control and Prevention (CDC), almost half of adults in the United States have some degree of gum disease.

The mechanisms behind periodontal disease are relatively well-understood, and newer research shows that this health problem may play a role in the development of a number of other conditions, including Alzheimer’s disease, cancer, and respiratory disease. In this Spotlight, we will cover some of the surprising links between gum disease and disparate health issues.

Gums and the brain

Although spatially the gums are near the brain, one wouldn’t normally associate dental complaints with neurological conditions.

However, some studies have found a link between periodontal disease and tooth loss and cognitive function. One study looking at cognitive performance followed 597 men for up to 32 years. The authors conclude:

Risk of cognitive decline in older men increases as more teeth are lost. Periodontal disease and caries, major reasons for tooth loss, are also related to cognitive decline.

Researchers have also linked periodontal disease with an increased buildup of beta-amyloid in the brain — the neurological hallmark of Alzheimer’s.

Other experiments have produced evidence that one type of bacteria commonly found in cases of periodontitis — Porphyromonas gingivalis — can be found in the brains of individuals with Alzheimer’s.

Following on from that discovery, in a more recent study, researchers showed that P. gingivalis infection boosts the production of beta-amyloid in the brain.

Periodontal disease was associated with a small, but significant, increase in overall cancer risk.

In this study, the researchers paid particular attention to an enzyme produced by P. gingivalis called gingipain. They found that this protease was toxic to tau, another protein that plays a pivotal role in Alzheimer’s.

It is worth noting that other researchers have concluded that beta-amyloid is produced in response to a pathogen. The way we view Alzheimer’s is slowly changing.

In the future, scientists hope that targeting gingipain enzymes might help stop neurodegeneration in some people with Alzheimer’s disease. They have already designed a gingipain inhibitor, which they are testing in humans.

Leave a Reply

Your email address will not be published. Required fields are marked *

Clinică adulți
https://meladent.md/wp-content/uploads/2023/12/image-07-12-23-07-31-3-640x444.jpeg
Adresă
Republica Moldova, Chișinǎu MD 2005; Bd. Grigore Vieru 26
061006090
ionlupu84@gmail.com
Clinică Copii
https://meladent.md/wp-content/uploads/2023/12/image-07-12-23-07-31-2-640x652.jpg
Adresă
Republica Moldova, Chișinǎu MD 2005; Bd. Grigore Vieru 22/8
078006090
ionlupu84@gmail.com
Urmariți-ne pe Facebook

3 weeks ago

Doctorul MelaDent
Recenziile pacienților noștri reprezintă principala sursă de motivație și inspirație! Svetlana, a obținut zâmbetul la care visa.Cu ajutorul serviciilor oferite de MelaDent, acum pacienta noastră zâmbește cu încredere!Când pacienții noștri zâmbesc și noi zâmbim!🤩 ... See MoreSee Less
View on Facebook

1 month ago

Zâna Măseluță
Dragii noștri cu ocazia zile internaționale a copilului dăm start celei de a 4-a ediție a tombolei! 🎈Tombola se va desfășura până pe data de 15 iulie!🤩📌Participă copii până la 12 ani!‼️Extragerea va avea loc în direct pe INSTAGRAM zana.maseluta‼️Câștigătorii vor fi contactați 📞 în direct ... See MoreSee Less
View on Facebook

Copyright 2023 MelaDent. All rights reserved.

Copyright 2023 by MelaDent. All rights reserved.